| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2025 , Vol 63 , Num 1
Protective benefits of quercetin and lipoic acid on methotrexate-induced oxidative stress in rat spleen
1 Institute of Health Sciences, Marmara University, Istanbul, Türkiye2 Department of Biochemistry, Faculty of Dentistry, Marmara University, Istanbul, Türkiye
DOI : 10.23893/1307-2080.APS6315 Viewed : 3341 - Downloaded : 1492 The study aims to examine the effect of Methotrexate (MTX) treatment on rat spleen and investigate the antioxidant properties of quercetin (Que) and lipoic acid (LA) on MTX. Rats were divided into groups as Controls, MTX-given group, MTX+Que-given group, and MTX+LA-given group. At the end of the experiment, total protein, glutathione (GSH), lipid peroxidation (LPO), nitric oxide (NO), and total sialic acid (SA) levels, also superoxide dismutase (SOD), and catalase activities were determined in spleen homogenates. MTX increased oxidant parameters and both Que and LA effectively decreased LPO, SA, and NO levels. Administration of MTX increased GSH levels and decreased SOD activity, besides Que normalized GSH level and SOD activity, LA decreased GSH activity. Que and LA may be effective in recovering MTX-induced toxicity by decreasing oxidative stress and can be useful in normalizing the damage situation in rat spleen. Keywords : methotrexate, oxidative stress, quercetin, lipoic acid, spleen