| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2025 , Vol 63 , Num 1
Phyto-metabolomic investigation and anti-migratory potential of Moringa oleifera Lam. and Moringa peregrina (Forssk.) Fiori against hepatic carcinoma cell line
1 Theodor Bilharz Research Institute, Department of Medicinal Chemistry, 12411, Giza, Egypt2 Theodor Bilharz Research Institute, Department of Biochemistry and Molecular Biology, 12411, Giza, Egypt
DOI : 10.23893/1307-2080.APS6310 Viewed : 3388 - Downloaded : 1446 The present study aims to characterize the active ingredients of Moringa oleifera (MO) and Moringa peregrina (MP) leaf extracts and evaluate their cytotoxic and anti-migration efficacies against liver cancer cells (HepG2). The chemical profiling of the aqueous and methanolic extracts of both Moringa species was carried out using LC-ESI-MS led to identifying of 37 compounds classified as flavonoids, phenolic acids, glucosinolate, and phenyl ethanoid. The MTT assay was used to assess the cytotoxic effect, which revealed to, the increasing of the MO and MP extracts" concentration adversely decreased the treated cells" viability. Treating of HepG2 cells by MO and MP for different time intervals effectively inhibited wound closure, while the cells migratory ability in the treated cells was decreased. This study reports that MO and MP extracts exhibited promising cytotoxic effects and inhibited migration of highly metastatic HepG2 cell lines, which may be due to the presence of polyphenolic compounds. Keywords : Moringa, anti-migration, HepG2, LC-ESI-MS, phenolic compounds