| Submission to first decision
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3 weeks |
|---|---|
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| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2025 , Vol 63 , Num 1
Effect of Ocimum gratissimum L. leaf extract on muscular atrophy in diabetic male wistar rats
1 University of Ibadan, Department of Physiology, Ibadan, Nigeria2 Ahmadu Bello University, Department of Human Physiology, Zaria, Nigeria
DOI : 10.23893/1307-2080.APS6307 Viewed : 3255 - Downloaded : 1570 Oxidative stress and inflammation precipitate muscular atrophy in diabetes mellitus. The antioxidant and anti-inflammatory activities of Ocimum gratissimum L. (OG) is well documented. Thus, the effect of OG on muscular atrophy in diabetic rats was investigated. Twenty rats grouped as Control, OG, Diab and Diab+OG were administered distilled water or OG for 28 days. Glycogen content was determined in gastrocnemius muscle, oxidative stress biomarkers were assessed in right rectus femoris and extensor digitorum longus muscles while histomorphometry analysis was done in the contralateral muscles. Elevated blood glucose and depleted glycogen content were observed in the Diab (204.75 ± 9.95mg/dl and 0.09 ± 0.03mg/ml) and reversed in Diab+OG (90.01 ± 26.50mg/dl and 0.36 ± 0.05mg/ml). The lengths of the rectus femoris and extensor digitorum longus muscles were reduced while malonaldehyde increased in Diab (0.420 ± 0.031?mol/l) compared with Diab+OG (0.370 ± 0.01?mol/l). In conclusion, OG prevented atrophy and promoted glycogenesis by decreasing lipid peroxidation in the skeletal muscles of diabetic rats. Keywords : muscular atrophy, diabetes mellitus, oxidative stress, Ocimum gratissimum L.