| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2025 , Vol 63 , Num 1
Development and evaluation of propolis loaded mixed micellar gel: Formulation, optimization and anticancer potential
1 Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Department of Pharmaceutics, Pimpri, Pune, Maharashtra, India2 Sinhgad College of Pharmacy, Department of Pharmaceutical Chemistry, Pune, Maharashtra, India
DOI : 10.23893/1307-2080.APS6301 Viewed : 3383 - Downloaded : 1633 To increase the effectiveness of the anticancer natural product propolis extract (PE), mixed micellar gel formulation composed of Pluronic F127 and Tween 80 was investigated. Cold technique was used to formulate mixed micellar gel loaded with propolis extract (PE-MMG). 32 factorial design was employed to optimize formulation. PE-MMG was characterized for micellar size, surface morphology, surface charge, drug loading, entrapment, release study and in vitro cytotoxicity. Developed optimized formulation showed desirable formulation characteristics Optimized formulation showed desirable characteristics for improved therapeutic performance. Enhanced cytotoxicity potential revealed through MTT Assay by PE-MMG as compared with PE showed enhanced permeability and chemosensitization. In overall developed formulation further studied as a promising carrier for cancer therapy. Keywords : mixed micellar gel, propolis, Pluronic F127, Tween 80, MCF 7