| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2024 , Vol 62 , Num 2
Sprayable microemulsion of diphenhydramine hydrochloride for dermal delivery
1 Istanbul Medipol University, School of Pharmacy, Department of Pharmaceutical Technology, Istanbul, Türkiye2 University of Health Sciences, Faculty of Pharmacy, Department of Pharmaceutical Technology, Istanbul, Türkiye
DOI : 10.23893/1307-2080.APS6229 Viewed : 5908 - Downloaded : 1957 In this work, a sprayable microemulsion of diphenhydramine hydrochloride (DPH HCl) was developed for use in conditions that cause itching, such as insect bites, mild sunburns, and skin irritations. Microemulsions were prepared using oleic acid and isopropyl myristate as the oil phase (1:2), Tween 20 and Transcutol HP as surfactants, isopropyl alcohol as co-surfactant, and water. The microemulsions (M1, M2, and M3) that presented greater area were selected as lead microemulsions and loaded with 2% DPH HCl (w/w). The physical stabilities of drug-loaded formulations with a droplet size of 15.998-19.030 nm, polydispersity index of 0.404-0.516, and turbidity of 2.41-2.50 Ntu were evaluated as appropriate. The microemulsions showed a great spread area in sprayability studies. Moreover, DPH HCl release from microemulsions reached 80-100% within one hour. The sprayable microemulsions were highly suitable for topical application of DPH HCl and can be evaluated for clinical applications with further studies. Keywords : diphenhydramine hydrochloride, microemulsion, dermal delivery, topical application, topical spray