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ACTA Pharmaceutica Sciencia 2024 , Vol 62 , Num 3
Essential oil composition of Isatis floribunda Boiss. ex. Bornm. and acetylcholinesterase inhibitory activity of its extract
Elif GÜZEL 1-2 Yasemin Yücel YÜCEL 3-4 Mustafa ALKAN 5 Kaan POLATOĞLU 6
1 Istanbul Medipol University, Institute of Health Sciences, Istanbul, Türkiye
2 Istanbul Medipol University, School of Medicine, Department of Medical Pharmacology, Istanbul, Türkiye
3 Altinbas University, Faculty of Pharmacy, Department of Biochemistry, Istanbul, Türkiye
4 Altinbas University, Natural Products Research and Development Center (DÜAGEM), Istanbul, Türkiye
5 Yozgat Bozok University, Faculty of Agriculture, Department of Plant Protection, Yozgat, Türkiye
6 Altinbas University, Faculty of Pharmacy, Department of Pharmacognosy, Istanbul, Türkiye
DOI : 10.23893/1307-2080.APS6237 This study aims to investigate the essential oil composition of aerial parts of Isatis floribunda, and the acetylcholinesterase inhibitory activity of its extracts. Essential oil of the aerial parts of the plant material was obtained and the GCMS analysis was performed. Then, extracts of the plant material were obtained, and in vitro acetylcholinesterase inhibitory assay was performed. GC-MS analysis demonstrated that the composition of Isatis floribunda is rich in fatty acid compounds, with the major compounds including dodecanoic acid, nanocosane, hexadecenoic acid, tetradecanoic acid, methyl octadecenoate, decanoic acid, and hexahydrofarnesyl acetone. Methanolic extract of the plant species has demonstrated strong acetylcholinesterase inhibitory activity with the IC50 value of 0.16 mg/mL. Essential oil composition of Isatis floribunda has been determined to be rich in fatty acid components, these compounds could demonstrate potent acetylcholinesterase inhibition. Therefore, a novel medication from Isatis floribunda extracts could be discovered against Alzheimer"s disease. Keywords : Isatis floribunda, acetylcholinesterase inhibition, Brassicaceae, GC-MS

Istanbul Medipol University