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ACTA Pharmaceutica Sciencia
2011 , Vol 53 , Num 1
STABILITY EVALUATION OF TAMOXIFEN CITRATE NANOEMULSION CONTAINING CREMOPHOR RH 40 AS SURFACTANT
Department of Pharmaceutics, M.E.S College of Pharmacy, A/P- Sonai-414105, Maharashtra, India
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The aim of the present study was to evaluate the stability of tamoxifen citrate using novel nanoemulsion formulation. Optimized nanoemulsion formulation of tamoxifen citrate was prepared by spontaneous emulsification method (aqueous titration method). Stability studies were performed for the period of 3 months. Droplet size, viscosity and refractive index (RI) were determined during storage. Shelf life of nanoemulsion formulation was also determined by accelerated stability testing. It was found that droplet size viscosity and RI were slightly increased at refrigerator and room temperature. The changes in these parameters were not significant (p < 0.05). The shelf life of nanoemulsion formulation was found to be 2.05 years at room temperature. These results indicated that stability of tamoxifen citrate can be enhanced in nanoemulsion formulation using cremophor RH 40 as surfactant.
Keywords :
TAMOXIFEN CITRATE, NANOEMULSION, STABILITY, CREMOPHOR RH 40