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ACTA Pharmaceutica Sciencia
2011 , Vol 53 , Num 1
SUPERPOROUS HYDROGELS AS GASTRORETENTIVE DEVICES
Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar-125001, INDIA
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One of the most feasible approaches for oral drug delivery in achieving a prolonged release and predictable drug delivery profile in the gastrointestinal tract (GIT) is to control the gastric residence time (GRT). The dosage forms with prolonged GRT also known as Gastroretentive Dosage Forms (GRDFs) include intragastric floating systems (low density systems), mucoadhesive systems, high density systems, magnetic systems, unfoldable, extendible or swellable systems and superporous hydrogels (SPHs). Superporous hydrogels (SPHs) are recent advancements of gastroretentive drug delivery systems. This article provides a concise review of superporous hydrogels along with their different generations, being fabricated for controlled release.
Keywords :
SUPERPOROUS HYDROGELS, INTERPENETRATING NETWORKS, GAS BLOWING TECHNIQUE, HYBRID HYDROGELS, GASTRORETENTIVE DOSAGE FORM, SUPERPOROUS HYDROGEL COMPOSITE