Acceptance rate 46%
Time to first decision 20 days*
Time to decision with review 50 days*

*approximate number of days

ACTA Pharmaceutica Sciencia 2022 , Vol 60 , Num 4
Formulation and evaluation of transdermal ultradeformable vesicles of aspirin
Imran PASHA 1 Arshad Bashir KHAN 1 Preethi SUDHEER 2
1 Department of Pharmaceutics, Krupanidhi College of Pharmacy, Chikkabellandur, Carmelram (PO), Bengaluru, Karnataka, India
2 Department of Pharmaceutics, Krupanidhi College of Pharmacy, Chikkabellandur, Carmelram, Varthur, Hobli, Bangalore, 560035, Karnataka, India
DOI : 10.23893/1307-2080.APS6025 Transfersomes are incredibly elastic and deformable vesicles composed of phospholipids and edge activators. This study proposed aspirin-loaded transfersomes for transdermal administration to prevent gastrointestinal side effects, boost drug permeation rate, and extend drug action. The formulations were prepared via the thin-film hydration method using soy lecithin as a vesicle forming agent and tween 80 as an edge activator. The formulation trials were optimized by "Custom design" JMP SW13. The optimum formulation yielded a vesicle size of 74.4 nm, a zeta potential of -27.4 mV, and a % entrapment efficiency of 90.5%±0.25 with a drug release of 88.65 %±0.34. A 1% carbopol gel incorporated the optimum formula. The homogeneous gel had a drug content of 95.8±1.5 %, a viscosity of 1762cP, a pH of 5.74±0.78, and % a drug release of 85.5%±0.85. The study concluded that transdermal transfersomes would be a promising approach to treating angina. Keywords : Transfersomes, Ultra-deformable, Vesicles, Phospholipids, Optimization

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