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ACTA Pharmaceutica Sciencia 2022 , Vol 60 , Num 3
Potent colon cancer cell line toxicity of the fruit extracts of Heptaptera triquetra (Vent.) Tutin
Fatma TOSUN 1 Mahmut MISKI 2
1 Department of Pharmacognosy, School of Pharmacy, Istanbul Medipol University, Istanbul, Turkey
2 Department of Pharmacognosy, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey
DOI : 10.23893/1307-2080.APS.6019 Cytotoxic activities of the fruit extracts of Heptaptera triquetra (Vent.) Tutin were investigated on the colon cancer COLO205 and KM12 cell lines. The dichloromethane extract of the fruits of H. triquetra showed the highest cytotoxic activities with IC50 values of 9.3 and 5.3 ug/mL on the COLO205 and KM12 cell lines, respectively. Whereas, the ethyl acetate extract of the fruits showed moderate cytotoxic activity with IC50 values of 22.3 ug/mL against the KM12 cell lines. Keywords : Cytotoxic activity, Heptaptera triquetra, Apiaceae

Istanbul Medipol University