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ACTA Pharmaceutica Sciencia 2022 , Vol 60 , Num 2
Evaluation of anti-diabetic and hypolipidemic effect of ethanolic extract of Waltheria indica against streptozotocin induced diabetes in mice
Ramasamy MUTHU 1-2 Ajay B1, ABU FAROQ 1 Karthikeyan ELUMALAI 3-4 Kannan DIRAVIAM 1 Gnanasekaran DHARMALINGAM 4
1 Department of Bioengineering, School of Chemical and Biotechnology, SASTRA University, Thanjavur - 613402, Tamilnadu, India
2 Department of Pharmacology, P.S.V. College of Pharmaceutical Sciences, Krishnagiri- 635108, India
3 Faculty of Pharmacy, Bharath Institute of Higher Education and Research, Selaiyur, Chennai-600073, India
4 Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai- 600 117, India
DOI : 10.23893/1307-2080.APS.6012 The present study was designed to investigate the anti-diabetic activity of ethanol extract of Waltheria indica leaves (EEWI) on streptozotocin induced diabetic mice. Effect of EEWI leaves antidiabetic and hypolipidemic effect was evaluated in streptozotocin (55 mg/ kg, i.p ) induced hyperglycaemic mice. EEWI (40 and 100 mg/ kg) was administered orally for 15 days. Glibenclamide (1mg/kg, orally for 15 days) was used as reference standard. The diabetic control animals exhibited a significant decrease in body weight compared with control animals. EEWI inhibited streptozotocin-induced weight loss and significantly alter the lipid levels. Administration of the EEWI caused significant dosedependent reduction in serum glucose, cholesterol, triglyceride and glycosylated haemoglobin % levels in streptozotocin induced hyperglycaemic animals. The ethanol extract of Waltheria indica leaves exhibited antidiabetic activity might be through increased secretion of insulin and, the effect attributed to the presence of flavonoids and phenolic compounds present in extract. Keywords : Diabetes mellitus, flavonoids, hypolipidemic, hyperglycaemia, streptozotocin

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