| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2021 , Vol 59 , Num 4
Flavonoids from Plant Source as Protein Tyrosine Phosphatase 1B Inhibitors: In Silico Update
1 Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmacy, Al Azhar University-Gaza, Gaza Strip, Palestine. https://orcid.org/0000-0001-5988-9 50592 Department of Biological Sciences, University of Jordan, Amman, Jordan
3 Hamdi Mango Center for Scientific Research, The University of Jordan, Amman
4 Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan
5 Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, UAE
DOI : 10.23893/1307-2080.APS.05939 Viewed : 19989 - Downloaded : 5047 Protein Tyrosine Phosphatase 1B (PTP1B) enzyme, type 1 non-transmembrane protein tyrosine phosphatase, is extensively expressed in different organs in the body and is linked to different signal transduction pathways including insulin signaling pathway. PTP1B inhibition exhibits significant effects on glucose homeostasis and glucose balance in blood and tissue. Several types of synthetic/natural compounds have been tested. Among these compounds, flavonoids showed high potency as PTP1B inhibitors. Different studies revealed that flavonoids could be promising PTP1B inhibitors with antidiabetic and weight loss effects. In recent years, the discovery of new flavonoids with PTP1B inhibition activity has been facilitated by the application of molecular modeling and computational methods. This review highlights the research efforts conducted in the discovery of flavonoids as PTP1B inhibitors and the role of computer-aided drug design techniques utilized in the discovery process. Keywords : PTP1B, flavonoids, inhibitory activity, In Silico, diabetes mellitus