| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2021 , Vol 59 , Num 4
Methanolic Leaf Extract of Dissotis Rotundifolia Alleviates Acetic Acid-Induced Ulcerative Colitis in Rats
1 Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana2 Division of Pharmacology/Toxicology, University of Missouri, Kansas City, USA
DOI : 10.23893/1307-2080.APS.05937 Viewed : 18341 - Downloaded : 4651 Dissotis rotundifolia (Sm.) Triana has been used locally in the treatment of inflammatory conditions such as painful swellings and conjunctivitis. This study aimed at investigating the effect of Dissotis rotundifolia in acetic acid-induced ulcerative colitis. Sprague Dawley rats were administered with Dissotis rotundifolia extract at doses 30, 100 and 300 mg kg-1 or sulfasalazine 500 mg kg-1 for 8 days. On the 4th day of treatment, colitis was induced by intrarectal administration of 1 ml, 4 %v/v acetic acid. On day 8, animals were sacrificed and parameters such as microscopic and macroscopic colon damage assessed. The extract exhibited significant (P < 0.0001) reduction in microscopic and macroscopic colon damage. 30 and 300 mg kg-1 of the extract significantly (P < 0.0001) inhibited weight loss and colon oedema. The leaf extract of Dissotis rotundifolia showed significant amelioration of acetic acidinduced ulcerative colitis which may be attributable to its anti-inflammatory effect. Keywords : Chronic inflammation, colon damage, Dissotis rotundifolia, oedema, ulcerative colitis