ACTA Pharmaceutica Sciencia 2021 , Vol 59 , Num 4
Correlation Between Oxidant and Antioxidant Status (MDA and SOD Expression) and the Improvement of Outer Hair Cells Function Due to Curcumin Administration in Noise-Exposed Rattus Norvegicus Cochlea Assessed by DPOAE Examination
Tengku Siti Hajar HARYUNA 1 Reastuty REASTUTY 1 Tengku Siti Harilza ZUBAIDAH 2 Delfitri MUNIR 1 Wibi RIAWAN 3 Juliandi HARAHAP 4
1 Department of Otorhinolaryngology, Faculty of medicine, Universitas Sumatera Utara, Medan, Sumatera Utara, 20155, Indonesia
2 Department of Ophtalmology, Faculty of medicine, Universitas Sumatera Utara, Medan, Sumatera Utara, 20155, Indonesia
3 Department of Biochemistry and Molecular Biology, Faculty of medicine, Brawijaya University, Malang, East Java, 65145, Indonesia
4 Department of Community Medicine, Faculty of medicine, Universitas Sumatera Utara, Medan, Sumatera Utara, 20155, Indonesia
DOI : 10.23893/1307-2080.APS.05931 NIHL caused by excessive noise exposed to cochlea. Curcumin is a medicine that has antioxidant effects. The purpose of this study was to look at the effect of curcumin on NIHL which was assessed with DPOAE, value and the expression of SOD and MDA. This research was conducted on 36 rats which were divided into 6 groups, group 1 was a control group, group 2 was a group receiving only noise treatment, groups 3 and 4 were the treatment group receiving curcumin after exposed to noise, groups 5 and 6 were preventive groups receiving curcumin starting from 14 days before their get noise. The study result showed the correlation between SOD and MDA expression and DPOAE value due to curcumin Administration in Noise- Exposed rats Cochlea. The conclussion of the study showed that curcumin was able to change the value of DPOAE, SOD and MDA expressions in rats exposed to noise. Keywords : Curcumin, noise, cochlea, antioxidants, superoxide dismutase

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