ACTA Pharmaceutica Sciencia 2021 , Vol 59 , Num 3
Physical Performance Enhancing Effects of The Aqueous Extract of Alysicarpus Ovalifolius in Mice
Lucy Binda JOHN-AFRICA 1 Lovelyn KesiennaELOUR 1 Samuel Ehiabhi OKHALE 2 Bulus ADZU 1
1 Department of Pharmacology and Toxicology
2 Department of Medicinal Plants Research and Traditional Medicine
DOI : 10.23893/1307-2080.APS.05930 Alysicarpus ovalifolius (fabaceae) is an herb used as ingredient of tea that is consumed as a tonic in Northern Nigeria. This study evaluated effects of aqueous extract of the aerial parts of Alysicarpus ovalifolius (AO) on physical performance in Swiss albino mice. Phytoconstituents were identified by HPLC. Performance was assessed by exhaustive swim, rotarod, four limb-hanging and hypoxia test. Effects on diazepam-induced sleep was also evaluated. HPLC detected presence of caffeic (60.34%) and chlorogenic acids (3.44%) and rutin (0.19%). The extract (100 ? 400mg/kg) produced significant (p<0.05) dose-dependent increase in swimming time; increased time spent on the rotarod and also increased duration in the fourlimb hanging test. No significant effect was observed in endurance to hypoxic condition. Diazepam-induced sleeping time was significantly decreased in AO-treated animals. These observations were comparable to caffeine (15mg/kg). The aqueous extract of Alysicarpus ovalifolius increased physical performance in mice by enhancing endurance, muscle strength and co-ordination. Keywords : Alysicarpus ovalifolius, endurance, swim, muscle strength

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