| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2021 , Vol 59 , Num 3
Significance of crude and degummed Citrullus lanatus seed oil on inflammatory cytokines in experimental infection induced by Candida albicans
1 Department of Biochemistry, University of Nigeria, NsukkaDOI : 10.23893/1307-2080.APS.05922 Viewed : 22841 - Downloaded : 4957 This study evaluated immunomodulatory and candidacidal properties of Citrullus lanatus seed oil (CLSO) on Candida albicans-infected rat. The immunomodulatory and candidacidal activities of both crude and degummed oil at varied doses were determined using 80 female albino rats, randomised into 10 groups of 8 rats per group based on the days 7 and 14 of study. Delayed hypersensitivity reaction showed a significant increase (p<0.05) in the hind paw oedema of rats treated with crude and degummed oil after 24 hours; however after 48 hour, a significant decrease (p<0.05) in hind paw oedema was observed. However, the CD4 + T-lymphocytes decreased at day 14 when compared with day 7 counterpart. In the same vein, IFN-γ and TNF-α decreased from day 7 to day 14 of the study; while IL-10 and IgA increased from day 7 to day 14 of the study. CLSO does not boost immune system, rather demonstrated anti-inflammatory activities of the oil. Keywords : Candidiasis; CD4 count; cytokines; degummed oil; immunosuppression