| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2021 , Vol 59 , Num 2
Formulation Design and Optimization of Sustained Released Matrix Tablets of Propranolol HCl Using Natural and Synthetic Polymers
1 Chitkara College of Pharmacy, Chitkara University, IndiaDOI : 10.23893/1307-2080.APS.05920 Viewed : 18730 - Downloaded : 4875 The proposed research work aimed to design, formulate and finally to evaluate sustained released matrix tablets of propranolol hydrochloride using the combination of hydrophilic and hydrophobic polymers. Formulation and optimization of Propranolol HCl was done by direct compression technique using 32 factorial design. The amount of polymer Mastic gum (X1) and HPMC (X2) were chosen as independent variables and their effect on amount of drug release at 2 hours (Y1) , 4 hours (Y2) and 8 hours (Y3) at three levels low (-1), medium(0) and high(+1) was taken as dependent variable. Drug-excipient compatibility studies were performed by FTIR and DSC analysis. A total of 9 combinations of sustained released tablets were formulated and evaluated for both pre and post compression parameters. Design expert software version 10 was used to evaluate the effect of independent variable over dependent variable and to generate polynomial equation to represent experimental results. The B7 formulation containing 5 % of mastic gum and 25% of HPMC K-15 combination showed 60.13% drug release in 8 hours and was chosen as optimized formulation. Release kinetic mechanism indicated that the optimized formulation fitted well into Kosmeyer Peppas model (R2= 0.9974). Stability studies indicated that selected formulation was stable for 90 days. Formulation containing 5% of mastic gum and 25% HPMC was found to be effective and can be explored further to develop sustained released formulations. Keywords : Sustained release, mastic gum, factorial design, propranolol HCl