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ACTA Pharmaceutica Sciencia 2019 , Vol 57 , Num 3
A Study of Drug-Excipient Interaction and Drug Product Stability Using Dry (Powder) Film Coating in Comparison with Conventional (Aqueous) Film Coating
Derar M. Omari 1 Yazan Akkam 1
1 Yarmouk University, Faculty of Pharmacy, Pharmaceutical Sciences, Irbid, Jordan
DOI : 10.23893/1307-2080.APS.05719 The objective of this work was to study drug-excipient interactions in solid dosage forms when coated with dry powder film-coat compared with conventional aqueous film. Free films of Eudragit RL, (ERL) with or without drugs (Metoprolol Succinate or Diclofenac sodium) were prepared by casting method and characterized by FTIR, NMR, or DSC. Tablets of either drugs were prepared by wet granulation and coated in a fluidized-bed by ERL aqueous dispersion or micronized powder. Dissolution behavior and color change study were carried out for tablet batches on zero time and after 3 months of storage in stability chambers. The results of free films showed a greater possibility of drug polymer interaction in the aqueous dispersion than dry powder films. The results of dissolution rate revealed a greater rate change in aqueous- than in dry-coated tablets. This was confirmed by the Color change study which showed more intense yellowing in aqueous-coated tablets. Keywords : Drug-excipient interaction, eudragit RL, diclofenac sodium, dry powder, coating

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