| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2019 , Vol 57 , Num 3
Flax Seed Mucilage-chitosan Polyelectrolyte Complex Nanoparticles: Optimization, Characterization and Evaluation
1 Guru Jambheshwar University of Science and Technology, Department of Pharmaceutical Sciences Hisar, IndiaDOI : 10.23893/1307-2080.APS.05716 Viewed : 19307 - Downloaded : 8187 The aim of this study is to prepare flaxseed mucilage (FSM) and chitosan polyelectrolyte complex (PEC) nanoparticles by ionic gelation method for developing sustained release formulation. For the formation of PEC nanoparticles, the water extract of flax seed is obtained by soaking the seeds in water overnight followed by precipitation with ethanol and washing with distilled water.FSM was interacted with fully protonated chitosan (in acetic acid 2% v/v) using Isonicotinylhydrazide (INH) as a model drug. The results of optimization study reveals that lower level of chitosan and flaxseed mucilage favors the lowest particle size.The optimum quantum of FSM and chitosan were found to be 0.011% (w/v) and 0.011% (w/v) respectively, that produced nanometric particles of size 326 nm with poly-dispersity index (PdI) of 0.217.The in vitro release profile of INH from the optimized batch was determined using the dialysis sac and it was found that INH get released over a prolonged period of 20 hours following Higuchi"s square root release kinetics with the combination of diffusion and erosion of matrix as release mechanism. It can be concluded from the present study that interaction between chitosan and FSM can be used for the formation of PEC nanoparticles and for developing sustained release formulation. Keywords : Flaxseed, chitosan, polyelectrolyte, complex, nanoparticles