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DOI : 10.23893/1307-2080.APS.05615 Viewed : 22237 - Downloaded : 6886 The objective of this study was to harness the excipient potential of date mucilage by co-grinding and co-fusing with avicel for enhanced performance in the directcompression of metronidazole.
Co-grinding and co-fusing of parent polymers were done using established methods and excipients were used in the direct-compression of metronidazole tablets.
The shape and surface morphology of the particles of date mucilage (DAM) and co-processed excipients were generally granular, rough and irregular. There was a significant improvement in the disintegration of tablets prepared using the coprocessed excipients in comparison to that prepared using DAM alone. The disintegration time for tablets prepared using co-fused excipients was lower than that of co-grinded additives although the differences were not significant (p > 0.05).
Generally, the co-processed excipients improved the mechanical and disintegration properties of the tablets produced compared to tablets prepared using DAM alone and could be further developed as direct-compression excipients.
Keywords : Date mucilage, avicel, co-processing, metronidazole tablets