Acceptance rate 46%
Time to first decision 20 days*
Time to decision with review 50 days*

*Approximate number of days

**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.


ACTA Pharmaceutica Sciencia 2018 , Vol 56 , Num 2
Synthesis, characterization and evaluation of antifungal activity of seven-membered heterocycles
Rasim Farraj Muslim 1 Hiba Mahir Tawfeeq 2 Mustafa Nadhim Owaid 3 Obaid Hasan Abid 4
1 Department of Ecology, College of Applied Sciences, University of Anbar, Hit 31007, Anbar, Iraq
2 Department of Chemistry, College of Education for Pure Sciences, Ramadi 31001, University of Anbar, Anbar, Iraq
3 Department of Heet Education, General Directorate of Education in Anbar, Ministry of Education, Hit, Anbar 31007, Iraq
4 Department of Scientific Affairs and Graduate Studies, University of Fallujah, Anbar, Iraq
DOI : 10.23893/1307-2080.APS.05610 This research includes synthesis of new heterocyclic derivatives of disubstituted 1,3-oxazepine-5-one. Azomethine compounds (N1-N5) were synthesized by the reaction of aromatic aldehydes with primary aromatic amines, in the presence of glacial acetic acid as a catalyst in absolute ethanol. The synthesized compounds were identified via spectral methods viz., FT-IR, 1H-NMR, and 13C-NMR and measurements of some physical properties. The prepared oxazepine compounds (N6-N10) were obtained from treatment of azomethine compounds with phthalide. N9 and N7 derivatives have recorded the higher zone of inhibition 15 mm against Candida guilliermondii and Candida zeylanoides respectively. The lower zone of inhibition was 8.0 mm and 9.3 mm by N7 toward the growth of Candida albicans and Candida guilliermondii respectively. Slight variation in the structure of those derivatives can show the very dramatic effect on the efficiency of these compounds in their bio-activity and may be helpful in designing more antifungal agents for therapeutic use in future. Keywords : Azomethine, anti-candidal activity, NMR, phthalide, oxazepine

Istanbul Medipol University