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ACTA Pharmaceutica Sciencia
2008 , Vol 50 , Num 3
EVALUATION OF VERATRIC ACID DERIVATIVES AS PRESERVATIVE IN ALUMINIUM HYDROXIDE GEL - USP
Hindu College of Pharmacy, Sonepat, Haryana
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The veratric acid (3,4-dimethoxy benzoic acid) derivatives from our earlier study were subjected to preservative efficacy testing in an official antacid preparation, (Aluminium Hydroxide Gel - USP) against Staphylococcus aureus MTCC 2901, Bacillus subtilis MTCC 2063, Escherichia coli MTCC1652, Candida albicans MTCC 227 and Aspergillus niger MTCC 8189 as representative challenging microorganisms as per USP guidelines. The veratric acid derivatives, 8-quinolinyl veratrate (P-2) and phenyl veratrate (P-3) were found to be effective in preventing contamination of the product during the test period. This study showed the potential of veratric acid derivatives to be chosen as preservatives in pharmaceutical products.
Keywords :
VERATRIC ACID, 8-QUINOLINYL VERATRATE, PHENYL VERATRATE, PRESERVATIVE, LOG CFU/ML