Acceptance rate 46%
Time to first decision 20 days*
Time to decision with review 50 days*

*Approximate number of days

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ACTA Pharmaceutica Sciencia 2017 , Vol 55 , Num 1
Synthesis and Antimycobacterial Activity Evaluation of Isatin-derived 3- [(4- aryl - 2- thiazolyl])hydrazone]-1H- indol- 2, 3- diones
Leyla Yurttaş 1 Merve Ertaş 2 Meral Yılmaz Cankılıç 3 Şeref Demirayak 2
1 Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 26470, Eskişehir, Turkey
2 Medipol University, School of Pharmacy, Department of Pharmaceutical Chemistry, 34810, İstanbul, Turkey
3 Anadolu University, Faculty of Science, Department of Biology, 26470, Eskişehir, Turkey
DOI : 10.23893/1307-2080.APS.0554 A series of 3-[(4-aryl-2-thiazolyl)hydrazone]-1H-indol-2,3-dione derivatives (2af) were designed and synthesized using isatin as starting material. The obtained thiazole compounds were screened to investigate their antituberculosis activity against Mycobacterum tuberculosis H37RV (ATCC 27294). Among them, two compounds 2c and 2d were displayed antitubercular potential two-fold greater than standard drugs. Keywords : Isatin, Indole, Thiazole, Antimycobacterial activity

Istanbul Medipol University