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ACTA Pharmaceutica Sciencia
2004 , Vol 46 , Num 3
KINETIC STUDIES ON THE GROWTH AND CYCLOSPORIN A PRODUCTION BY A LOCAL ISOLATE OF FUSARIUM OXYSPORUMI, NRC
Natural and Microbial Products Chemistry Department, National Research Center, Dokki, Cairo, Egypt
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The kinetics of cyclosporin A (Cy A) production by F. oxysporum NRC were studied in both shaking flask and bioreactor (5L capacity) cultures. Both the volumetric and specific production values of Cy A were higher by about 73.5% and 57.1% in case of adopting the bioreactor culture technique, respectively. In addition, more vigorous fungus growth was observed with the bioreactor culture. On glucose limitation, the fungal biomass yield nearly remained almost constant, while Cy A production was stimulated under the same conditions, wherein maximum Cy A yield (349.2 mg/1) was obtained after 10 days incubation.
Keywords :
CYCLOSPORINE A PRODUCTION, FUSARIUM OXYSPORUM