| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2016 , Vol 54 , Num 1
Synthesis and antimicrobial activity evaluation of novel nitrofuranthiazoles
1 Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 26470, Eskişehir, Turkey2 Medipol University, School of Pharmacy, Department of Pharmaceutical Chemistry, 34810, İstanbul, Turkey
3 Medipol University, School of Pharmacy, Department of Pharmaceutical Microbiology, 34810, İstanbul, Turkey
DOI : 10.23893/1307-2080.APS.0544 Viewed : 16557 - Downloaded : 5698 In this work, six novel 4-aryl-2-[2-((5-nitrofuran-2-yl)methylene)hydrazinyl] thiazole derivatives (2a-f) were synthesized starting from 5-nitro-2-furaldehyde diacetate by using Hantzsch thiazole synthesis. The antimicrobial activity of the title compounds were screened against five Gram positive bacteria B. cereus, E. faecalis, S. aureus, S. epidermidis, L. monocytogenes and two Gram negative bacteria E. coli and S. typhi. MIC and MBC were calculated and compared to standard drug nitrofurazone. Compounds bearing pyridine moiety (2d-e) exhibited significant antimicrobial activity which could be evaluated as new, potent antibacterial agents. Keywords : nitrofurans, nitrofurazone, thiazole, antibacterial activity