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ACTA Pharmaceutica Sciencia
2004 , Vol 46 , Num 1
SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF SOME 2-[ (DIALKYLAMINOTHIOCARBONYLTHIO )ACETAMIDO]-5-NITROTHIAZOLE DERIVATIVES
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of AI-Azhar - Gaza, Palestine
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In tills study, some novel 2-[(dialkylaminothiocarbonylthio)acetamido]-5-nitrothiazole derivatives were synthesized by reacting 2-(chloroacetamido)-5-nitrothiazole and an appropriate potassium N,N disubstituted dithiocarbamate. Their structures have been elucidated by IR, 1H-NMR spectral data and elemental analyses. The antibacterial and antifungal activities of the obtained compounds were investigated in vitro and appreciable activities were obtained.
Keywords :
5-NITROTHIAZOLE, DITHIOCARBAMATE, ANTIMICROBIAL ACTIVITY