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ACTA Pharmaceutica Sciencia
2010 , Vol 52 , Num 1
FORMULATION AND EVALUATION OF LIPOSOMES CONTAINING ANTITUBERCULAR DRUGS BY TAGUCHI‘S ORTHOGONAL ARRAY DESIGN
Al-Ameen College of Pharmacy, Bangalore, India
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Isoniazid (INH) and rifampicin (RIF) are effective drugs for treatment of tuberculosis (TB). Considering effectiveness of combine drug therapy of INH and RIF, the study focused on formulation of liposomes. The objective of this study was to achieve desired entrapment of antitubercular drugs (rifampicin and isoniazid) in liposome. The liposomes were produced by thin film evaporation technique using soya phosphatidylcholine. The evaluation studies of different processing variables like drug to lipid ratio, phosphatidyl choline to cholesterol ratio, temperature and hydration time were evaluated by Taguchi design on percentage drug entrapment (PDE), size distribution, release rate, particle size. Liposomes showed encapsulation efficiency of 79.69%± 2.260 for RIF and 47.54% ±1.19 for Isoniazid. Liposomes containing both Rifampicin and Isoniazid were optimized based on the individual optimized formulation. Liposomes obtained have average vesicle size of 14.66 μm in case of single drug liposome and 18.19 μm in case of liposomes containing both drugs (INH AND RIF). Thus it was possible with Taguchi OA design of optimization to prepare liposome containing hydrophilic and hydrophobic.
Keywords :
LIPOSOMES, ANTITUBERCULAR DRUGS, MULTILAMELLAR VESICLES, LYOPHILIZATION, DRUG RELEASE