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ACTA Pharmaceutica Sciencia
2010 , Vol 52 , Num 2
EXACERBATED CARDIAC INJURY INDUCED BY RENAL ISCHEMIA/REPERFUSION IN DIABETES MELLITUS-II
Department of Pharmacology, Smt. RBPMPC, Atkot - Rajkot, Gujarat, India
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The present work was designed to investigate the role of Diabetes Mellitus Type-II (DM-II) on renal ischemia reperfusion (I/R)-associated pathophysiology in cardiac damage. DM-II in rats was induced by the administration of nicotinamide (230 mg/kg, i.p.) and streptozotocin (65 mg/kg, i.v.). In vivo renal I/R was performed in both DM-II and normal rats. Lipid peroxidation, xanthine oxidase activity, and nitric oxide levels were significantly increased in cardiac tissue after I/R in diabetic rats compared to I/R in normal rats. Levels of antioxidant enzymes were significantly reduced after I/R in diabetic rats compared to normal rats. Serum TNF-α levels and cardiac tissue myeloperoxidase activity were also significantly increased after I/R in DM-II rats. In conclusion, DM-II rats showed exaggerated cardiac damage by renal I/R injury.
Keywords :
DIABETES TYPE-II, ISCHEMIA, REPERFUSION, HEART, INFLAMMATION, OXIDATIVE STRESS