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ACTA Pharmaceutica Sciencia
2010 , Vol 52 , Num 2
DESIGN OF MUCOADHESIVE VAGINAL METRONIDAZOLE FILMS
Dept. of Pharmaceutics, Prin. K.M.K. College of Pharmacy, Colaba, Mumbai, India
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A mucoadhesive drug delivery system for local availability of Metronidazole through vaginal route was formulated. Metronidazole films were prepared by solvent evaporation method using various compositions of Carbopol, HPMC and plasticizers like Sorbitol, Glycerine, PEG 400 and PG. The films were evaluated for their weight, thickness, surface pH, folding endurance, drug content uniformity, in vitro drug release and mucoadhesion. Films containing 10% PG and Carbopol-HPMC in the ratio of 1:1 and 1:2 represented optimal composition as they showed accepatable, physical, mechanical, drug release and mucoadhesion characteristic for vaginal delivery of Metronidazole proposed for local contraception.
Keywords :
METRONIDAZOLE, VAGINAL FILMS, CARBOPOL, HPMC, MUCOADHESION, CONTRACEPTION