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ACTA Pharmaceutica Sciencia
2010 , Vol 52 , Num 4
PREPARATION AND CHARACTERIZATION OF 5-FU LOADED MICROSPHERES OF EUDRAGIT AND ETHYLCELLULOSE
Smt. R.B. Patel Mahila Pharmacy College, Atkot, Gujarat. India
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In the present investigation 5-fluorouracil loaded microspheres of Eudragit (RS 100, RL 100 and RSPO) and ethylcellulose were prepared. “O/O solvent evaporation” technique was used for preparation of microspheres using (methanol + acetone)/liquid paraffin system. Magnesium stearate was used as the droplet stabilizer and n-hexane was added to harden the microspheres. The prepared microspheres were characterized for their micromeritic properties and entrapment efficiency; as well by Fourier transform infrared spectroscopy (FTIR) and thin layer chromatography (TLC). Photomicrographs were taken to study the shape of microspheres. The best fit release kinetics was achieved with Higuchi plot. Mean particle size, entrapment efficiency and production yields were highly influenced by the type of polymer and polymer concentration. It is concluded from the present investigation that various Eudragit and ethylcellulose are promising controlled release carriers for 5-FU.
Keywords :
5-FLUOROURACIL, EUDRAGIT RS 100, EUDRAGIT RL 100, EUDRAGIT RSPO, ETHYLCELLULOSE, MICROSPHERES, SOLVENT EVAPORATION