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ACTA Pharmaceutica Sciencia
2011 , Vol 53 , Num 2
A NEW ISOFLAVONE FROM JACARANDA OBTUSIFOLIA H.B.K. SSP. RHOMBIFOLIA (G.F.W. MEIJER) GENTRY
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A new isoflavone (1), along with daidzein (2), and genistin (3) were isolated from the Jacaranda obtusifolia twig extract. Their structures were elucidated by NMR and MS spectroscopy. Compound 1 possessed significant anticancer activity against KB and NCI-H187 cell lines with the IC50 values of 2.52 and 7.47 ?g mL-1, compound 2 and 3 exhibited anticancer activity against KB and NCI-H187 cell lines with the IC50 values of 5.73, 8.14, 2.83 and 27.30 ?g mL-1, respectively. Compound 2 also showed anticancer activity against MCF-7 cell line with an IC50 value of 28.17 ?g mL-1. The isolates showed noncytotoxic against Vero cells.
Keywords :
JACARANDA OBTUSIFOLIA, BIGNONIACEAE, ISOFLAVONOIDS, ANTICANCER ACTIVITY, CYTOTOXICITY