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ACTA Pharmaceutica Sciencia
2009 , Vol 51 , Num 3
A COMPARATIVE IN VITRO EVALUATION OF ENTEROPOLYMERS FOR PULSATILE DRUG DELIVERY SYSTEM
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Enteric coatings are pH sensitive and can be considered as a pulsatile drug delivery system because of the lag time is essential for the drugs that undergo degradation in gastric acidic medium which irritate the gastric mucosa. The present study explores the comparative utility of the enteropolymers (enteric-coated polymers) such as acrycoat L-100, acrycoat S-100, ethyl cellulose (EC) and cellulose acetate phthalate (CAP) in developing a suitable dosage form, exhibiting a minimum drug release in the upper regions of the gastrointestinal tract (GIT) on order to provide site specificity as well as time controlled formulation. Core tablets of diclofenac sodium (DS) were prepared by wet granulation and coated with one of the coating polymers to a varying coating level. From the dissolution data obtained, it was found that the dissolution rate was inversely proportional and lag time was directly proportional to the coating level applied. Comparative dissolution data revealed that, of all the various polymers at varying coating level used, a 15% acrycoat S 100 and EC was most suitable for pulsatile drug delivery. Moreover, such study also provides a site specific drug delivery.
Keywords :
PULSATILE DRUG DELIVERY, ENTEROPOLYMERS, SITE SPECIFIC, LAG TIME, IN VITRO DRUG RELEASE