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ACTA Pharmaceutica Sciencia 2011 , Vol 53 , Num 2
Abstract PDF Similar Articles
DESIGN, DEVELOPMENT, AND OPTIMIZATION OF MOUTH DISSOLVING TABLETS OF LEVOCETIRIZINE DIHYDROCHLORIDE USING CENTRAL COMPOSITE DESIGN
SONİA DHİMAN, SURENDER VERMA, S K SİNGH
Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Indi Viewed : 18171 - Downloaded : 6457 The aim of the present research work was to design and develop an optimized mouth dissolving tablet dosage form of an anti-allergic drug, Levocetirizine dihydrochloride. Independent variables such as the amount of subliming agent-camphor (X1) and the amount of superdisintegrant-crospovidone (X2) were optimized using a 2-factor, 3-level Central Composite Design. The dependent variables selected were the disintegration time, wetting time, cumulative % drug release in 10 min. and water absorption ratio of the tablet. The mathematical relationships were generated using multiple linear regression analysis and all the polynomial equations were found to be statistically significant (P<0.0002), as determined using ANOVA. Keywords : MOUTH DISSOLVING TABLETS, LEVOCETIRIZINE DIHYDROCHLORIDE, SUPERDISINTEGRANT, SUBLIMING AGENT, CENTRAL COMPOSITE DESIGN

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