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ACTA Pharmaceutica Sciencia
2009 , Vol 51 , Num 1
EFFECTS OF QUININE TREATMENT ON SOME INDICES OF PROTEIN METABOLISM IN PLASMODIUM FALCIPARUM INFECTED HUMAN SUBJECTS
Department of Chemical Pathology, Faculty of Clinical Sciences, University of Uyo, Uyo, Akwa Ibom State, Nigeria
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This study highlights the effects of quinine sulphate on some indices of protein metabolism in Plasmodium falciparum infected and healthy human subjects. A total of 40 Plasmodium falciparum infected patients (20 untreated and 20 treated with therapeutic dose of quinine for 3 days) and 30 apparently healthy subjects (20 untreated and 10 receiving quinine sulphate for malaria chemoprophylaxis, were studied. Serum levels of bilirubin, urea creatinine, total protein, albumin and globulin were determined in all the subjects using appropriate chemical techniques. Increased bilirubin, urea, creatinine, globulin, and decreased total protein and albumin were observed in untreated infected patients, whereas quinine treatment to healthy subjects increased serum bilirubin and globulin levels. However, treatment of malaria infected subjects with quinine ameliorated these malaria associated biochemical changes except the persistence of high globulin level. Although quinine appeared to be immunogenic and caused haemolysis in some patients, it showed an ability to restore host metabolic activities which had been deranged by Plasmodium falciparum infection.
Keywords :
MALARIA, PLASMODIUM FALCIPARUM, QUININE, PROTEIN METABOLISM