| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2010 , Vol 52 , Num 3
THE INFLUENCE OF VARIATION OF GASTRIC PH ON THE GELATION AND RELEASE CHARACTERISTICS OF IN SITU GELLING SODIUM ALGINATE FORMULATIONS
Department of Pharmaceutics, Smt. R.B.Patel Mahila Pharmacy College, Atkot, Gujarat, India
Viewed :
19045
-
Downloaded :
5899
The aim of present study was to examine the influence of variation of gastric pH over the range 1-3.5 on the gelation of liquid formulations of sodium alginate and on the in vitro release of baclofen from the resultant gels. Gels suitable as vehicles for sustained delivery of these drugs were formed in vitro at pH < 3.5 from sodium alginate solutions of concentrations 1.0-2.5% w/v. Very weak gels were formed at pH 3.0 resulting in poor sustained release characteristics compared with those at pH 1.2; no significant in vitro gelation was observed at pH 3.5. Visual observations showed in situ gelation of 1.5% (w/v) sodium alginate formulations under conditions of both high (pH 1.0-1.6).
Keywords :
IN SITU GELATION, SODIUM ALGINATE GELS, BACLOFEN