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ACTA Pharmaceutica Sciencia
2010 , Vol 52 , Num 3
THE INFLUENCE OF VARIATION OF GASTRIC PH ON THE GELATION AND RELEASE CHARACTERISTICS OF IN SITU GELLING SODIUM ALGINATE FORMULATIONS
Department of Pharmaceutics, Smt. R.B.Patel Mahila Pharmacy College, Atkot, Gujarat, India
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The aim of present study was to examine the influence of variation of gastric pH over the range 1-3.5 on the gelation of liquid formulations of sodium alginate and on the in vitro release of baclofen from the resultant gels. Gels suitable as vehicles for sustained delivery of these drugs were formed in vitro at pH < 3.5 from sodium alginate solutions of concentrations 1.0-2.5% w/v. Very weak gels were formed at pH 3.0 resulting in poor sustained release characteristics compared with those at pH 1.2; no significant in vitro gelation was observed at pH 3.5. Visual observations showed in situ gelation of 1.5% (w/v) sodium alginate formulations under conditions of both high (pH 1.0-1.6).
Keywords :
IN SITU GELATION, SODIUM ALGINATE GELS, BACLOFEN