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ACTA Pharmaceutica Sciencia
2009 , Vol 51 , Num 3
VALIDATED STABILITY INDICATING LC-DAD METHOD FOR DETERMINATION OF OLMESARTAN MEDOXOMIL IN TABLETS EXPOSED TO STRESS CONDITIONS
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A sensitive and precise LC-DAD method was developed and validated for the determination of olmesartan medoxomil in the presence of its degradation products. Olmesartan medoxomil with its degradation products was resolved on a C18 column with mobile phase composed of methanol, acetonitrile and water (60:15:25 v/v/v; pH 3.5±0.5 by orthophosphoric acid) at 202 nm on DAD. Each peak resolved always with a resolution of >2.0 indicating the method to be specific and selective. Four degradation products (DP-I, II, III, IV) were formed during degradation study.
Keywords :
OLMESARTAN MEDOXOMIL, STRESS DEGRADATION, LIQUID CHROMATOGRAPHY-DAD, STABILITY INDICATING