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ACTA Pharmaceutica Sciencia
2007 , Vol 49 , Num 1
IN VITRO AND IN VIVO EVALUATION OF GELLAN BASED OCULAR INSERTS OF PHENYLEPHRINE
Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar- India
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Gellan gum based ocular inserts of phenylephrine were prepared by solvent casting method, and evaluated for uniformity of thickness, weight, drug content, surface pH, in vitro release and in vivo mydriatic response in rabbits. The inserts were found to release drug following Higuchi square root release kinetics. In vivo comparison of the inserts with three times dosing of the conventional eye drop formulation revealed a comparable intensity and extent of mydriatic response produced by inserts. It can be concluded from the study that gellan gum based ocular inserts of phenylepherine can be effectively used for sustained topical ocular delivery.
Keywords :
GELLAN GUM, PHENYLEPHERINE, MYDRIATIC RESPONSE, OCULAR INSERT