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ACTA Pharmaceutica Sciencia
2007 , Vol 49 , Num 1
FORMULATION AND IN VITRO CHARACTERIZATION OF SODIUM ALGINATE-GELLAN BEADS OF GLIPIZIDE
ISP (Hong Kong) Limited, Bhupal Towers, Rajbhavan Road, Soamjiguda, Hyderabad, India
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Glipizide beads of sodium alginate alone and in combination with gellan were prepared by ionotropic gellation method. The prepared beads were evaluated for their physico-chemical characteristics like particle diameter, surface morphology, encapsulation efficiency, swelling and gelling rate and in vitro drug release characteristics. The effect of various formulation variables like polymer concentration (sodium alginate, and proportion of gellan in beads prepared by a combination of sodium alginate and gellan), drug loading, drying conditions, crosslinking agent concentration and curing time on in vitro dissolution of the prepared beads were evaluated. The results showed that both the diameter and the encapsulation efficiency of beads proportionally were increased with the increase in polymer concentration. In case of beads containing both sodium alginate and gellan, the mean diameter and the encapsulation efficiency were higher than the corresponding beads containing only alginate, and both were increased with an increase in proportion of gellan. The prepared beads were spherical in shape and were successful in sustaining drug release for 8 hours. Incorporation of gellan caused a significant decrease in drug release. The drug release followed a biphasic profile, in all cases, characterized by an initial phase of high drug release followed by a phase of moderate release. Further, the kinetic treatment of the drug release data revealed the prevalence of matrix diffusion kinetics.
Keywords :
GLIPIZIDE, SODIUM ALGINATE, GELLAN, CONTROLLED RELEASE, BEADS