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ACTA Pharmaceutica Sciencia
2007 , Vol 49 , Num 1
HYPO AND HYPERGLYCEMIA; INDICATORS FOR COMPARATIVE PHYSIOLOGIC EVALUATION OF CHLOROQUINE, FANSIDAR, MALAREICH AND MALOXINE
Department of Physiology, Faculty of Basic Medical Sciences, University of Uyo,Akwa Ibom State, Nigeria
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Blood glucose levels were determined colorimetrically for 28 (4 weeks) days in thirty five albino rats with the administration of chloroquine, fansidar, malareich and maloxine in comparative doses. Fansidar decreased blood glucose concentration, (43.3 mg/dl) in the first week of the drug administration but a follow up observation of the drug action showed an increase (141.2-135.3 mg/dl) in blood glucose level in the second and third weeks. However, a normal value (82.4 mg/dl) of the blood glucose was obtained in the fourth week of the follow up observation. Chloroquine also exhibited low blood glucose (65.5 mg/dl) in the first week of the administration but normal values were recorded from the second to the fourth week of the follow up. The two new drugs malareich and maloxine maintained normal concentrations of blood glucose throughout the study. It is concluded that fansidar has the tendency of inducing diabetis.
Keywords :
NEW AND OLD ANTIMALARIALS, HYPOGLYCEMIA, HYPERGLYCEMIA