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DOI : 10.23893/1307-2080.APS.05612 Viewed : 18466 - Downloaded : 6128 The aim of present study was to evaluate the protective effects of Coleus forskohlii against Gentamicin (GM)-induced nephrotoxicity in male albino wistar rats.
Thirty rats were divided into five groups (n=6). Control rats received normal saline. Nephrotoxicity was induced in rats by gentamicin (80mg/Kg, IP) and treated with Silymarin (100mg/Kg, p.o,), aqueous and ethanolic extracts of (500mg/Kg, p.o) C. Forskohlii respectively for 15days. Markers of renal function (urea, uric acid and Creatinine), antioxidant markers were evaluated along with histopathological investigation in all experimental groups.
GM-treated rats showed significant increase in serum levels of renal markers, TBARS and decrease in GSH, SOD, CAT. Histopathological examinations of GMtreated rats revealed degenerative changes in glomeruli and renal tubules. Administration of aqueous and ethanolic root extracts of Coleus forskohlii, protected the kidney tissues against toxic effects of gentamicin as evidenced by amelioration of histopathological changes and normalization of kidney biochemical parameters.
The results of present study confirm the nephroprotective and anti-oxidant activity of C. forskohlii.
Keywords : Coleus forskohlii, gentamicin, nephrotoxicity, antioxidant activity