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ACTA Pharmaceutica Sciencia
2017 , Vol 55 , Num 4
On the Relationship Between Serum Apelin Levels and Some Parameters Related to Oxidative Stress and Energy Metabolism in Obese and Non-Obese
1 Division of Biochemistry Faculty of Medicine, Medipol University, Istanbul, TurkeyDOI : 10.23893/1307-2080.APS.05523 Viewed : 18725 - Downloaded : 5614 Adipose tissue plays an important role in energy balance by secretion of various adipokines. Obesity is excessive fat accumulation in the body. The aim of this study is to examine the association of apelin, an adipokine secreted from fat tissue, with antioxidant system, glucose and lipid parameters in obese and control cases. After approval has been taken from the Ethics Committee, 61 obese and 24 control people were included in the study. The ages in the study group ranges between 18 and 75. The body mass index (BMI) is >24.9 in obese people, and it ranges between 18.5 - 24.9 in control cases. Apelin was calculated using the ELISA method, total oxidant and total antioxidant levels were calculated using the colorimetric method, fasting blood glucose, insulin, TG, LDL and HDL levels were calculated using the photometric method, insulin resistance was calculated using the HOMA-IR method. Serum apelin levels were not found to differ between obese and control groups (p>0.05). Total antioxidant level (TAS) decreased in the obese group (p<0.001) while total oxidant level (TOS) remained the same. The Oxidative Stres Index (OSI) increased (p<0.001) in the obese group. In the obese group, glucose and insulin resistance were high (p<0.05) while serum insulin levels were the same as in the control group (p>0.05). In our study group, lipid parameters did not exhibit any difference in the obese and control groups. There was a significant relationship at p<0.05 level between triglyceride values in the control and obese case groups, while there were no significant differences among other lipid parameters.
As a result; we think that further studies are needed to understand the effect of apelin, which is released from fat tissue and is active in energy metabolism.
Keywords : Obesity, apelin, oxidative stress, adipose tissue