| Submission to first decision
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3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2017 , Vol 55 , Num 2
Antimicrobial Activity Evaluation Of New 1,3,4-oxadiazole Derivatives
1 Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Anadolu University, 26470 Eskişehir, Turkey2 School of Pharmacy, Department of Pharmaceutical Chemistry, Medipol University, 34810, İstanbul, Turkey
3 Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Anadolu University, 26470 Eskişehir, Turkey
DOI : 10.23893/1307-2080.APS.05511 Viewed : 18673 - Downloaded : 5580 In this study, we have synthesized seven novel 2-[(5-(4-chlorobenzyl)-1,3,4-oxadiazol- 2-yl)thio]-N-(6-substituted benzothiazol-2-yl)acetamide derivatives (4ag) starting from ethyl 4-chlorophenyl acetate. The antimicrobial acitivity of the compounds was screened against seven Gram positive and Gram negative bacteria and four fungi species; Escherichia coli ATCC 25922, Escherichia coli ATCC 35218, Enterococcus faecalis ATCC 51299, Enterococcus faecalis ATCC 29212, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Candida albicans, Candida krusei, Candida glabrata, Candida parapsilosis. Minumum inhibitor concentration (MIC) was calculated and compared with standard drugs, chloramphenicol and ketoconazole. Regarding the results of MIC, all compounds exhibited potency either at the higher concentrations or at the same concentrations compared with positive controls. Keywords : 1,3,4-oxadiazole, benzothiazole, antibacterial, antifungal