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ACTA Pharmaceutica Sciencia
2010 , Vol 52 , Num 2
SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME NEW BENZOTHIAZOLE DERIVATIVES
G.H.G Khalsa College of Pharmacy, Gurusar Sadhar-141104, Ludhiana, Punjab, India
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In the present study, seven new derivatives (R1 to R7) of benzothiazoles were synthesized and evaluated their anti-bacterial activity. p-toluidine on reacting with ammonium thiocynate formed 2-benzothiazolamines, which on reacted with hydrazine hydrate formed hydrazino derivative. Compounds (R1 to R7) were synthesized by reacting hydrazine derivative with different acetophenones (2‘-fluoroacetophenone, 4‘-fluoroacetophenone, 2‘-Chloroacetophenone, 4‘- Chloroacetophenone, p- Hydroxyacetophenone, 2‘- Hydroxyacetophenone, 2, 5- Dihydroxyacetophenone). All the synthesized compounds were identified by IR, NMR. The anti-bacterial activity were investigated and appreciate activity were observed.
Keywords :
BENZOTHIAZOLE, SUBSTITUTED ACETOPHENONES, ANTI-BACTERIAL ACTIVITY