Acceptance rate 46%
Time to first decision 20 days*
Time to decision with review 50 days*

*Approximate number of days

**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.


ACTA Pharmaceutica Sciencia 2017 , Vol 55 , Num 4
Formulation of Microemulsions for Dermal Delivery of Cephalexin
Neslihan Üstündağ Okur 1 Sevda Er 2 Emre Şefik Çağlar 1 Tarık Ziya Ekmen 1 Furkan Sala 1
1 Istanbul Medipol University, School of Pharmacy, Department of Pharmaceutical Technology, Beykoz, 34810 Istanbul, Turkey
2 Anadolu University, Yunus Emre Vocational School for Health Services, 26470 Eskişehir, Turkey
DOI : 10.23893/1307-2080.APS.05524 Introduction: Cephalexin monohydrate (CEM) is mostly used because of its activity against both the gram-positive and gram-negative microorganisms for infections. Microemulsions offer numerous advantages for dermal delivery of drugs.

Objective: The objective of the present study was to prepare novel CEM loaded microemulsions and to characterize formulations, to evaluate their in vitro release profiles and antibacterial activities.

Method: CEM loaded formulations [0.02% (w/w)] were characterized according to their droplet size, zeta potential, PDI, pH, electrical conductivity and viscosity. In addition, in vitro drug release studies and antibacterial activity tests were performed.

Results: The developed CEM loaded microemulsions (M1 and M2) achieved narrow droplet size distribution (152.75±4.85 and 128.05±9.22), low PDI (0.364±0.05 and 0.489±0.06), suitable pH (5.28-4.84) and conductivity (342±4.472-374±5.477 µS/cm). Zeta potential was measured as 0.209±0.041 and 0.141±0.024 mV. M1CEM showed 100% release at the 7th hour and was provided almost the same zone diameter as CEM solution when evaluated for antibacterial activity.

Conclusion: Overall, it was concluded that microemulsions might be beneficial in improving dermal delivery of CEM for the treatment of skin and soft tissue infections. Keywords : Cephalexin, microemulsion, dermal delivery, in vitro release, antibacterial activity

Istanbul Medipol University