| Acceptance rate | 46% |
|---|---|
| Time to first decision | 20 days* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2017 , Vol 55 , Num 1
Synthesis, Antimicrobial Activity Studies and Molecular Property Predictions of Schiff Bases Derived from ortho-Vanillin
1 İstanbul Medipol University, School of Pharmacy, Kavacık Mah. Ekinciler Cad. No.19 Kavacık Kavşağı, TR-34810, Beykoz, İstanbul, TurkeyDOI : 10.23893/1307-2080.APS.0556 Schiff bases are known to possess anticancer, antibacterial, antifungal, antitubercular, anti-inflammatory, antibacterial and antimalarial properties. At the same time, in recent years, prediction of drug-likeness, molecular, absorption, distribution, metabolism, and excretion (ADME) properties using in silico techniques has become a standard procedure for the evaluation of clinical usable molecules. In this study, Schiff base structured 2-methoxy-6-{[(2-alkyl/arylethyl)imino]methyl}phenol derivatives were synthesized from 3-methoxysalicylaldehyde (o-vanillin). The antibacterial and antifungal activities of these compounds were determined against Staphylococcus aureus, Escherichia coli, Candida albicans and Pseudomonas aeruginosa using agar-well diffusion and broth microdilution techniques. Further analysis was conducted using the in silico technique to predict the drug-likeness, molecular and ADME properties of these molecules. Among all the compounds, 2-{[(4-fluorophenethyl)imino]methyl}-6-methoxyphenol (Compound 9) exhibited the highest activity with good minimum inhibition concentration and radius of inhibition zone values against Candida albicans. Keywords : Schiff bases, Antifungal, Candida albicans, Molecular properties, In silico