Acceptance rate | 46% |
---|---|
Time to first decision | 20 days* |
Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2006 , Vol 48 , Num 3
OPTIMIZATION OF DRUG-POLYMER MIXING RATIO IN ALBENDAZOLE-POLYVINYLPYRROLIDONE SOLID DISPERSION BY MOISTURE ABSORPTION STUDIES
Novel Drug Delivery Department, Ranbaxy Research Labs, Gurgaon, Haryana, India
The main aim of the study was to investigate the moisture absorption behavior and the molecular mobility of albendazole-polyvinylpyrrolidone solid dispersions. Moisture gain magnitude of the dispersions was found to be significantly less compared to the amorphous physical mixture upon equilibration with 75% RH. Such decrease in moisture absorption magnitude was found to be high at 35-50% polymer content. The extent of plasticization of absorbed water was observed to be minimum at 50% polymer content. Therefore, the drug-polymer weight ratio was optimized to be 1:1 for obtaining the physically stable dispersion. Morphology of the solid dispersion of 1:1 drug-polymer mixing ratio was investigated using scanning electron microscopy. The tablets (equivalent to 400 mg of albendazole) formulated using this solid dispersion complied with the pharmacopoeial dissolution requirement.
Keywords :
ALBENDAZOLE, SOLID DISPERSION, MOISTURE ABSORPTION, PLASTICIZATION, CRYSTALLIZATION