ACTA Pharmaceutica Sciencia 2010 , Vol 52 , Num 4
2,4-SUBSTITUTED DIPHENYL-5-IMINO-Δ2-1,3,4-THIADIAZOLE DERIVATIVES: SYNTHESIS AND EVALUATION OF ANTIMICROBIAL PROPERTIES
MOHAMMAD ASİF, CHHAVİ ASTHANA
Department of Pharmacy, GRD (P.G) Institute of Management and Technology, Rajpur, Dehradun, India Some new subsituted-2,4-diphenyl-5-imno-1,3,4-thiadiazole derivatives were synthesized and studied for their antibacterial activity. These compounds were prepared from reaction of benzoyl chloride and phenyl hydrazine in pyridine yielded the corresponding substituted hydrazonoyl derivatives (1a-h) which were chlorinated to the corresponding α-chlorobenzal phenylhydrazone derivatives (2a-h). Reaction of Compounds (2a-h) with potassium thiocyanate yielded the targeted compound 2,4-diphenyl-5-imino-Δ2- 1,3,4-thiadiazole derivatives (3a-h). These compounds were characterized by CHN analyses, IR, mass and 1H NMR spectral data. All the compounds were evaluated for their in vitro antibacterial activity against two Gram negative strains (Escherichia coli and Pseudomonas aeruginosa) and two Gram positive strains (Bacillus cereus and Staphylococcus aureus) and their minimum inhibitory concentration (MIC) were determined. The newly synthesized compounds exhibited promising antimicrobial activities. Keywords : ANTIBACTERIAL ACTIVITY, HYDRAZONYL, 1,3,4-THIADIAZOLE DERIVATIVES, MINIMUM INHIBITORY CONCENTRATION.

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