ACTA Pharmaceutica Sciencia 2010 , Vol 52 , Num 4
SYNTHESIS, ANTICONVULSANT ACTIVITY AND COMPARATIVE QSAR STUDY OF SOME NOVEL 1,2,5-TRISUBSTITUTED BENZIMIDAZOLE DERIVATIVES
JİTENDER SİNGH, PARUL GROVER, DHARAM PAL PATHAK
Lord Shiva College of Pharmacy, Sirsa-125055, Haryana, India In view of obtaining some potential anticonvulsant compounds we have synthesized a series of 1,2,5- trisubstituted benzimidazoles derivatives (6a-6j, 7a-7j, 8a-8j). The results of QSAR investigation and the study of various physicochemical properties indicates that the change in linker at position one (R1) does not change the activity of the synthesized compounds and optimum chain length at position two (R2) is responsible for the anti-convulsant activity. The results also showed that the synthesized compounds with electron withdrawing group at position five (R3) shows better anti-convulsant activity as predicted by QSAR studies. Keywords : SUBSTITUTED BENZIMIDAZOLES; SYNTHESIS; ANTI-CONVULSANT ACTIVITY; QSAR

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