ACTA Pharmaceutica Sciencia 2010 , Vol 52 , Num 4
DESIGN AND OPTIMIZATION OF MUCOADHESIVE HYDROPHILIC MATRIX TABLET CONTAINING ATENOLOL USING CENTRAL COMPOSITE DESIGN
MAHENDRA NAKARANİ, DHAVAL J PATEL, DİPEN R BHİMANİ, JAYVADAN K PATEL, SUBHASH S VAGHANİ
Unison Pharmaceuticals Limited, Ahmedabad, Gujarat, India The current study involves development of oral mucoadhesive hydrophilic matrices of atenolol, and optimization of their in vitro drug release profile and ex vivo mucoadhesion against goat intestinal mucosa. A 32 central composite design (CCD) was employed to systematically optimize the drug delivery formulations containing two polymers, viz., chitosan-652 and hydroxypropyl methylcellulose K100MCR (HPMC K100MCR). Response surface plots and contour plots were drawn, and optimum formulations were selected by feasibility and grid searches. Both the polymers had significant effect on the mucoadhesive strength of the tablets, measured as force of detachment against goat intestinal mucosa. Validation of the formulation optimization study carried out using six confirmatory runs, indicated a very high degree of prognostic ability. The study successfully undertook the development of an optimized once-a-day formulation of atenolol with excellent mucoadhesive and controlled release characteristics. Keywords : ATENOLOL, EXPERIMENTAL DESIGN, MUCOADHESIVE, RESPONSE SURFACE METHODOLOGY, CENTRAL COMPOSITE DESIGN

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