| Acceptance rate | 46% |
|---|---|
| Time to first decision | 20 days* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2011 , Vol 53 , Num 2
SYNTHESIS OF NOVEL NITRIC OXIDE DONATING PYRAZOLES
Chitkara College of Pharmacy, Village-Jansla, Tehsil- Rajpura, Patiala, India
A series of 1-aryl-5-(4-hydroxy) phenyl pyrazoles was synthesized via reaction of various aromatic chalcones with substituted phenylhydrazine in ethanol. Nitric oxide donor group i.e., nitrate was introduced by treating synthesized pyrazoles with a mixture of fuming nitric acid and acetic anhydride in chloroform in cold conditions. Nitric oxide has low solubility in water and is unstable in the presence of various oxidants. It makes it difficult to introduce as such into biological systems in a controlled or specific fashion. Therefore, development of chemical agents that release NO is important. Pyrazole compounds have been identified as potent COX inhibitors with good pharmacokinetic profiles. These reports prompted us to undertake the synthesis of some novel pyrazoles with NO-donating properties.
Keywords :
NITRIC OXIDE, PYRAZOLES, PHENYL, PHENYLHYDRAZINES